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Chichibabin pyridine synthesis : ウィキペディア英語版 | Chichibabin pyridine synthesis
The Chichibabin pyridine synthesis ( ) is a method for synthesizing pyridine rings. In its general form, the reaction can be described as a condensation reaction of aldehydes, ketones, α,β-Unsaturated carbonyl compounds, or any combination of the above, in ammonia or ammonia derivatives. It was reported by Aleksei Chichibabin in 1924.〔name = 'AEC1924ori'>〕 The following is the overall form of the general reaction: :420px ==Reaction mechanism== The elementary contributing steps of the reaction mechanism can be classified as more familiar name reactions, including an imine synthesis, a base-catalyzed aldol condensation, and initiating the ring-synthesis step, a Michael reaction.
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